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Altered State is begonnen op 10 februari 1996 aan de Papengracht 3 te Leiden
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Preferred sulfonating agents are sulfuric acid, chlorosulfonic acid and/or sulfuric trioxide.
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This suggests that even a drug of 1% solubility provides a significantly dissolved state of drug in the matrix, resulting in a contribution of drug diffusion to the overall release kinetics
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Food and Drug Administration came with a companion DNA test (previously, only one drug had required such a test)
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